报告题目：“Multi-cellular Aggregation in Bacterial Systems”
报告题目：“Circadian Biological Clock”
报告人：Prof. Bernd Schüttler，University of Georgia
Prof. Bernd Schüttler acquired doctoral degree from University of California, Los Angeles in 1984. Now, he currently works as professor in Department of Physics and Astronomy, University of Georgia. His research focus on condensed matter theory, numerical and simulation studies of quantum many-body systems, applications of statistical mechanics in computational biology and systems biology. He has authored more than 100 scientific papers, which are published in the journals including Phys. Rev. Lett., Phys. Rev. B, Appl. Phys. and Low Temp. Phys.
Collective cell movement is critical to the emergent properties of many multicellular systems including microbial self-organization in biofilms, embryogenesis, wound healing, and cancer metastasis. However, even the best studied systems lack a complete picture of how diverse physical and chemical cues act upon individual cells to ensure coordinated multicellular behavior. Known for its social developmental cycle, the bacterium Myxococcus xanthus utilizes coordinated movement to generate three-dimensional aggregates called fruiting bodies. Despite extensive progress in identifying genes controlling fruiting body development, cell behaviors and cell-cell communication mechanisms that mediate aggregation are largely unknown.
Oscillators, by virtue of their periodic dynamics, provide a way to tell time, as illustrated by the periodic movement of a clock’s pendulum. The study of coupled oscillators and their mutual synchronization has remained a problem central to physics for centuries, but has also captured the imagination of biologists in recent times. One example of synchronized oscillators are the circadian biological clocks found in living cells. Biological clocks are pervasive in their effects from genes to ecosystems. Biological clocks affect the health of animals and plants and they are being engineered for timed delivery of therapeutics, algal bioreactors for biofuel production, and crop improvement. The clock, through its light entrainment feature, impacts the genetic dynamics of bacterial assemblages in the world’s oceans and hence may affect carbon cycling in marine ecosystems. Understanding how cell populations synchronize their clock oscillations, to give rise to a fully functional “biological clock”, is therefore of substantial interest in current systems biology research.