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计算机科学技术名家讲座(八)-Xiuli Zhang

2017-07-02 22:21 管理员 次阅读

报告题目:Neoantigen  in Cancer Immunotherapy

报告时间:6月7日  下午13:30

报告地点:计算机楼A521报告厅

报告人:Xiuli  Zhang

报告人简介:

 Xiuli Zhang currently works  as a Senior Scientist in the Department of Surgery, Washington University in  Saint Louis. Her research focus on pre-clinical and clinical trial study of  personalized cancer vaccine and immunotherapy. She has twenty years of research  experiences in the area of vaccine development (cancer, virus, bacteria),  mucosal immunology, cellular immunology and molecular microbiology, especially  strong experience with T cell function in cancer immunotherapy with neoantigen  and checkpoint blockade. Her work has extended to immunohistochemistry and  confocal microscope areas with both section slide and whole tissue  observation. She has authored more than 20 scienctific papers, which  are published in the journals including nature, J Clin Invest, Cancer  Immunology Research, PLoS Pathog, and J. Immunology.

报告摘要:

  Next-generation sequencing technologies have provided insights into the biology  and mutational landscape of cancer. Here we evaluate the relevance of cancer  neoantigens in murine cancer model (Sarcoma and breast cancer) and human cancers  (breast cancer). we sequenced  exomes of tumor and normal cells. We identified numerous nonsynonymous somatic  mutations. A computational analysis identified and prioritized MHC class  I–restricted candidate neoantigens expressed in the dominant tumor  clone. Each  candidate neoantigen was evaluated using peptide-binding assays,  immunogenicity in vivo and in vitro, and preclinical models in  which we measured antitumor immunity. Our results demonstrate that cancer  neoantigens can be recognized by the immune system, and that  CD8+ T cells enriched for  prioritized cancer neoantigens were able to protect mice from tumor challenge.  We conclude that next-generation sequencing and epitope-prediction strategies  can identify and prioritize candidate neoantigens for immune targeting in breast  cancer.

主办单位: 吉林大学计算机科学与技术学院

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